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Pharmacodynamics I
⏱ 18:34
12/30
Progress
Q12 Agonists
A patient on long-term beta-blocker therapy suddenly stops his medication. He presents 48 hours later with severe rebound hypertension and tachycardia. The pharmacodynamic mechanism responsible is:
A
Tachyphylaxis of cardiac receptors to catecholamines
✗
B
Up-regulation of β-adrenoceptors now exposed to catecholamines
✓
C
Increased catecholamine synthesis in the adrenal medulla
D
Down-regulation of adrenergic receptors throughout the body
📖 Explanation
Chronic antagonist use causes receptor up-regulation — more β-receptors are inserted into the membrane. Abrupt withdrawal exposes this increased receptor population to circulating catecholamines, producing a rebound sympathomimetic response. This is why beta-blockers must never be stopped suddenly.
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